Speaker: Marco Stampanoni, Villigen/CH
Moderators: Maria Adele Marino, Messina/IT; Pascal Baltzer, Vienna/AT

What can you expect from this webinar?
When X-rays penetrate a specimen, they are partially absorbed, refracted, and scattered. Nowadays, image contrast in conventional medical X-ray imaging relies exclusively on absorption and its sensitivity tends to get poorer the softer the tissue is. During the last years, significant efforts have been invested in translating high-sensitive X-ray techniques pioneered at synchrotron facilities into medical devices. Those efforts include developments on novel X-ray optics and methods, dedicated X-ray detectors, novel signal retrieval and processing as well as image analysis. Our team has focused on gratings interferometry, a technique originally developed to measure fundamental properties of a synchrotron beam (such as source size and divergence) and that further evolved into a sophisticated tool for advanced X-ray imaging in the lab and, recently, even for clinical applications. The capability of grating interferometers to generate image contrast exploiting refraction and scattering, rather than absorption, can potentially revolutionize the radiological approach to medical imaging because they are intrinsically capable of detecting subtle differences in the electron density of a material (like a lesion delineation) and of measuring the effective integrated local small-angle scattering power generated by the microscopic structural fluctuations in the specimen (such as micro-calcifications in a breast tissue).

In this Webinar I will provide an intuitive insight into the working principle of gratings interferometry and illustrate the status of the developments of new medical devices relying on this technology aiming at improving sensitivity and specificity of both mammography (2D) and CT (3D) breast imaging towards a precise and painless early breast cancer detection.

Speaker: Magda Marcon, Zurich/CH
Moderators: Marianna Fanizza, Pavia/IT; Ritse M. Mann, Nijmegen/NL

Speakers: Elisabetta Giannotti, Nottingham/UK; Valeria Romeo, Naples/IT
Moderator: Doris Leithner, New York/US

What can you expect from this webinar?
The Webinar aims at providing an overview on the current status and relevance of AI applications in the breast screening programme, with particular attention not only to digital mammography but also digital breast tomosynthesis. Background of current limitations and need of improvement of breast screening programme will be described, also explaining why breast imaging is such a great platform for AI and why AI has become the recent hot topic in breast imaging. Then clinical premises for the use of AI tools in breast cancer screening will be illustrated. Basics principles of AI techniques applied to digital mammography and digital breast tomosynthesis for breast cancer screening will be presented and its main clinical implementation options described. Finally, medico-legal implications of using AI tools in breast cancer screening will be discussed.

What will you learn during this webinar?
– To understand the clinical premises of the use of AI for breast cancer screening.
– To learn about the principles of AI techniques applied to digital mammography and digital breast tomosynthesis for breast cancer screening.
– To be aware of the main clinical implementation options of AI techniques in breast cancer screening.

Speaker: Eva M. Fallenberg, Munich/DE
Moderators: Federica Leone, Milan/IT; Monique Dorrius, Groningen/NL

Speaker: Jonathan James, Nottingham/UK
Moderators: Nisha Sharma, Leeds/UK, Elisabetta Giannotti, Nottingham/UK

What can you expect from this webinar?
Contrast enhanced mammography (CESM) has been used in the symptomatic breast service in Nottingham for over 7 years. The webinar will describe the routine use of CESM at our centre, review the evidence from our own practice and the literature and provide a case-based review of CESM in symptomatic setting.

What will you learn during this webinar?
– To understand the evidence for the use of CESM in a symptomatic breast clinic
– To see how CESM can assist the local staging of symptomatic primary breast cancer
– To become familiar with reporting CESM in the symptomatic setting

Speaker: Fabienne Thibault, Paris/FR
Moderator: Daly Avendano, Monterrey/MX; Katja Pinker, New York/US

What can you expect from this webinar?
Contrast-enhanced Mammography (CEM) is being increasingly used in routine practice. Using a panel of clinical cases, we will illustrate its main indications and its contribution to oncological diagnosis and therapeutic management. This includes diagnostic work-up of suspicious findings on mammography and/or US, determination of the initial tumour extent, evaluation of response to systemic treatment, aiding preoperative lesion localisation and diagnosing cancer recurrence. The clinical performance of CEM will be discussed in comparison with conventional mammography and ultrasound, and with breast MRI.

What will you learn during this webinar?
− The utility of CEM in daily practice both at the diagnostic stage and during the successive steps of breast cancer management
− Getting aware of advantages and limitations of CEM compared to breast MRI
− Getting to know some particular features of CEM images encountered during interpretation

Speaker: Marc Lobbes, Sittard-Geleen/NL
Moderators: Thiemo van Nijnatten, Maastricht/NL; Rubina Manuela Trimboli, Milan/IT

What you can expect from this webinar?
Contrast-enhanced mammography (CEM) is an upcoming breast imaging modality that relies on the injection of iodine based contrast agent and dual-energy mammography. The increased acceptance of CEM can be deducted from the increasing amount of installments and growing number of scientific publications. CEM indications might include: problem solving tool in equivocal findings during conventional mammography, preoperative staging, response monitoring in women treated with NAC, high risk screening, etc. However, it also starts with acquiring a robust CEM image. Hence, the current webinar will focus on the technical principles of CEM, patient handling and image acquisition. Some of the most common questions when initiating CEM within your breast center will be addressed, as well as the most common indications for CEM.

What can you learn during this webinar?
– Learn how to set up a CEM program in your hospital.
– Learn to acquire a high quality CEM image and know the technical principles behind it.
– Learn to cope with the most common artefacts and pitfalls.
– Discuss the most common indications for CEM.

Speaker: Daniela Bernardi, Milan/IT
Moderator: Lucia Grana, Lugo/ES

Speaker: Sophia Zackrisson, Malmö/SE
Moderator: Heike Preibsch, Tübingen/DE

What can you expect from this webinar?
This lecture will cover the basics and advances of digital breast tomosynthesis, DBT, and its role in breast cancer screening and clinical breast imaging. Scientific background data will be presented, and cases will be used to illustrate pearls and pitfalls with DBT in different situations.

What can you learn during this webinar?
– the technique behind digital breast tomosyntesis, strengths and limitations
– the current scientific evidence and recommendations for use of DBT in screening
– clinical situations where DBT might be useful

Speaker: Francesca Caumo, Verona/IT
Moderator: Elisabetta Giannotti, Nottingham/UK

What can you expect from this webinar?
Decide to undergo screening is an individual choice. The main questions are: how large the benefit of screening is in terms of reduced breast cancer mortality and how substantial the harm is in terms of interval cancers (defined as a cancer diagnosed after a negative mammographic screen and before the next routine screen), reduction of sensibility of mammography in dense breast and overdiagnosis, which is defined as the detection of cancers with screening which would not have become clinically apparent in the woman’s lifetime in the absence of screening.

There are two strategies to improve the effect of a screening program: find a better first level test- Automated Breast Ultrasound System (ABUS)-Magnetic Resonance Imaging (MRI)-Digital Breast Tomosynthesis (DBT)-Hand-Held Ultrasound (HHUS) or try the way to overcoming effect of density and make a better risk classification to have different screening strategies including other imaging modalities, in addition to mammography, that might improve early detection of breast cancer.
International strategy (Wisdom Study; Dense Study, MyPeBs) is thinking about tailored screening modifying interval screen and using other modality.

The objective of the webinar is to describe this experience and show our project: RiBS (RiskBasedScreening)